Best B Vitamins for People with MTHFR

This post is meant for a very specific group of people (which may include you…without even realizing it).  Several years ago, I tested positive for a genetic mutation in my MTHFR genes; these are genes responsible for methylation.  I describe methylation in detail below, but essentially, when your body is doing it properly ~ it means all the systems in your body are working together, optimally.  The best supplements for supporting methylation are undoubtedly high-quality B Vitamins.  In this article, we’ll discuss the “Best B Vitamins for People with MTHFR,” ones I’ve used myself with great success for many years, that have dramatically increased my energy levels.

Best B Vitamins for People with MTHFR, How to Get More Energy Naturally with Proper B VItamins, Girl Who Travels the World

Supplementing with methylated B vitamins is now a regular part of my wellness routine, & has dramatically improved my energy levels.


What is Methylation?

A simple way of explaining methylation is that it allows the gears in your body to turn smoothly. It affects MULTIPLE processes, such as DNA & neurotransmitter production, fat metabolism, eye & liver health, & detoxification. Folate, or 5-MTHF, is critical for turning on ONE important switch in your body ~ without which, a number of important molecules cannot be created. 


For people with an MTHFR mutation, or deficiency, it’s almost certain that optimal methylation is NOT being achieved. In this case, proper supplements can make a huge difference to reach optimal health.

How Can I Test for MTHFR?

If you want to test for an MTHFR mutation, your doctor will need to order a genetic test, which is typically a simple blood test.  This is not a typical test; the only reason my doctor ordered it was to determine possible causes for adrenal issues; a lack of B vitamins can contribute to adrenal fatigue.  Genetic testing can be expensive, but many insurance companies are now covering it.

It’s also possible to have a genetic test performed independently, by MTHFR Doctors ($129).  It involves a simple, cheek swab test ~ no needles necessary.  The main problem with this route is that you’ll need to have someone analyze your results.  In my opinion, it’s better to seek guidance from a physician, who’ll be able to look at the big picture ~ as MTHFR is merely one factor in what could be potentially be several issues impacting optimal health.

Essential Nutrients for Methylation


There are seven specific nutrients that help the methylation cycle achieve optimal performance, even if an individual has a genetic mutation that slows down or hinders the methylation cycle.  An MTHFR mutation can be inherited from one or both parents.

  1.  5-MTHF (active folate)
  2.  Methylcobalamin (active vitamin B12)
  3.  Pyridoxal 5’-Phosphate (active vitamin B6)
  4.  Riboflavin 5’-Phosphate (active vitamin B2)
  5.  Magnesium
  6.  Betaine (also known as trimethylglycine)
  7.  Vitamin D

For a more extensive article on the “why” behind taking B Vitamins, & how they can be used to give you more energy: read this article.

What’s Wrong with “Regular” B Vitamins?

The problem with “regular” B vitamins is that they use cheaper, synthetic versions of B ~ like riboflavin (the cheap kind that’s in many cereals) & folic acid.  If you have MTHFR, both riboflavin & folic acid can be toxic to your body; your body doesn’t know what to do with them, & doesn’t know how to convert them into usable energy. 

After I got the results of my genetic test, my doctor went through all my supplements ~ to make sure I wasn’t taking ANY of the cheaper forms of Vitamin B anymore.

Side-by-Side Comparison

Just so you know how different methylated Vitamin B is from a “regular” brand ~ here’s a side-by-side comparison.  Below on the left, are the ingredients in Nature Made’s Super B Energy Complex.  We’ll compare & contrast that with the brand I use, which is Pure Therapeutics Pharmaceutical Grade Methyl B.

  • Vitamin B-2 = 1.7 mg (100% DV) of Riboflavin in Nature Made, vs. 25 mg (1,470%) of active Riboflavin-5′-Phosphate-Sodium in Pure Therapeuticals.  
  • Vitamin B-6 = 2mg (100% DV) of Vit. B-6 as Pyridoxine Hydrochloride, vs. 15 mg (750%) of Vit. B-6 (as Pyridoxal-5′-Phosphate).
  • Vitamin B-9 = 400 mcg (100% DV) of Folic Acid, vs. 2,000 mcg (500% DV) of Folate (as Methylfolate & Quatrefolic)  
  • Vitamin B-12 = 6 mcg (100% DV) of Cyanocobalamin, vs. 1,000 mcg of Adenosylcobalamin & Methylcobalamin 

Pure Therapeuticals is like B Vitamin on steroids.  Not only is the quantity of ingredients greater, but the quality is better & more available to the body, to be used & converted into energy.  And perhaps the most potent ingredient is methylated B-12 ~ many people receive this as a shot from their doctor, & often notice a difference in their energy levels almost immediately. 

Best B Vitamins for People with MTHFR

The supplements shown below are ones I personally use, & ideal for people with MTHFR gene mutations. 

1) Pure’s Vitamin B-complex, which I’ve already discussed; & 2) Adrenal Assist ~ which not only has B vitamins, but magnesium, Vitamin C, & a host of adaptogens like Ashwaghanda, Rhodiola, & Holy Basil.  This formula is excellent for those with adrenal issues or adrenal fatigue, as adaptogens adapt to your body, giving you precisely the support you need. When I use Adrenal Assist, I feel an almost immediate “boost” of energy, yet with none of the jitters I associate with having excess caffeine.

Pure Therapeutics Methyl-B


Adrenal Assist


Best B Vitamins for People with MTHFR

Other supplements that will assist your body with methylation & overall immunity are magnesium & the all-important Vitamin D; my preferred (& most bio-available) formulas can be found below.

Please Note: This article documents what has worked for me, as someone with a moderate MTHFR mutation.  If you are concerned about switching supplements or have questions, please consult your doctor before trying any new supplements.

xoxo Noelia

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Why Methylated B Vitamins are Better than Regular B Vitamins, Girl Who Travels the World

Best B Vitamins for People with MTHFR, Girl Who Travels the World